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Do our cannabinoid receptors have anything to do with cannabis?

  Not really. The fact that the chemicals found in cannabis (phytocannabinoids) interact with our cannabinoid receptors is sheerly coincidental. Cannabinoids, the endocannabinoid system, cannabinoid receptors, all of those things were named after cannabis because research into the plant is what led to their discovery in 1992. They’re not named after cannabis because cannabis is the only thing that interacts with them, it’s just paying homage to the herb. Vertebrates first evolved the endocannabinoid system (ECS) 525 million years ago during the Cambrian explosion. Every vertebrate on the planet has this system, and this system mostly interacts with endocannabinoids found within our bodies that we naturally produce, such as AEA and 2AG. Cannabis first appeared 2.3 million years ago in an area that humans hadn’t yet migrated to. Your ECS is responsible for regulating vital functions in the body like sleep, pain sensitivity, mood regulation, inflammation, appetite, body heat, muscle tone